abstract：:Erythropoietin (EPO), known for its role in stimulating erythropoiesis, has recently been shown to have a cardio-protective effect in animal models of myocardial ischemia-reperfusion (I-R) injury. The mechanism of the cardio-protective effect of EPO is unclear. Part of the mechanism for EPO-induced cardio-protection m...

journal_title：Annals of clinical and laboratory science

authors： Xu B,Dong GH,Liu H,Wang YQ,Wu HW,Jing H

更新日期：2005-04-01 00:00:00

abstract：:This study assessed the progression of renal damage in obese Zucker rats in response to deoxycorticosterone acetate (DOCA)-salt-induced hypertension. Renal damage was evaluated by light microscopy and urine analysis at weekly intervals during the developmental phase of DOCA-salt hypertension and once during the platea...

journal_title：Annals of clinical and laboratory science

authors： Morrison RG,Carpenter AB,Adams VL,Mangiarua EI,Wehner PS,McCumbee WD

更新日期：2005-01-01 00:00:00

abstract：:We report 2 patients who presented with vasomotor symptoms and severe thrombocytopenia following rattlesnake bites. These symptoms persisted in spite of treatment with antivenin and transfusion of multiple doses of platelets. Thrombocytopenia is a common occurrence in moderate to severe crotaline envenomation. Algorit...

journal_title：Annals of clinical and laboratory science

authors： Odeleye AA,Presley AE,Passwater ME,Mintz PD

更新日期：2004-10-01 00:00:00

abstract：:To investigate the relationships of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), anthropometric variables, and lipid parameters, we measured serum TRAIL concentrations, body mass index (BMI), total body fat (TBF), and serum lipid profiles in 207 healthy adults. There were no significant diffe...

journal_title：Annals of clinical and laboratory science

authors： Choi JW,Song JS,Pai SH

更新日期：2004-10-01 00:00:00

abstract：:Urine p-aminophenol (PAP) concentration serves as a biological marker for occupational exposures to aniline. We report the development of a rapid, simple spectrophotometric method for quantification of urine PAP concentration using a chemical autoanalyzer (Olympus Reply). The method involves oxidative coupling of PAP ...

journal_title：Annals of clinical and laboratory science

authors： Chen CF,Tseng YT,Tseng HK,Liu TZ

更新日期：2004-07-01 00:00:00

abstract：:To identify markers sensitive to inhibitors of the farnesylation pathway, we used 3 breast cancer cell lines (SKBR-3, MDA-175, and MDA-231) to evaluate the in vitro effects of pamidronate, an inhibitor of farnesyl diphosphate synthase. In response to pamidronate, there was significant inhibition of cell proliferation ...

journal_title：Annals of clinical and laboratory science

authors： Zhang PL,Lun M,Siegelmann-Danieli N,Blasick TM,Brown RE

更新日期：2004-07-01 00:00:00

abstract：:Male Sprague-Dawley rats were subjected for 2 weeks to daily injections of homocysteine (Hcy), which increased plasma Hcy approximately 2-fold. Echocardiography indicated significant increases in left ventricular diastolic (13%) and systolic (31%) dimensions and decreases in posterior wall thickness (diastolic, -17%; ...

journal_title：Annals of clinical and laboratory science

authors： Walker E,Black J,Parris C,Bryda EC,Cansino S,Hunt L,Chappell J,Wehner P,Studeny M,Wright GL

更新日期：2004-04-01 00:00:00

abstract：:In vitro determination of allergen-specific IgE (sIgE) represents an important aid in the diagnosis and treatment of allergy. Improvements in laboratory methodology--the development of second, and now third generation assays for sIgE--have brought about major advances in speed, convenience, performance, and in the sta...

journal_title：Annals of clinical and laboratory science

authors： Li TM,Chuang T,Tse S,Hovanec-Burns D,El Shami AS

更新日期：2004-01-01 00:00:00

abstract：:Hydroxyethyl starch (HES) has been shown to be beneficial in several inflammatory situations, but the mechanisms are unclear. The present study tested the hypothesis that HES has effects on nuclear factor kappa B (NF-kappaB) activation and the expression of inflammatory mediators induced by lipopolysaccharide. Sepsis ...

journal_title：Annals of clinical and laboratory science

authors： Tian J,Lin X,Zhou W,Xu J

更新日期：2003-10-01 00:00:00

abstract：:We report a case of a 69-yr-old previously healthy man with acute spontaneous Achilles tendon rupture and severe tendonitis, which occurred after 2 weeks of steroid therapy for newly diagnosed giant cell arteritis. The Achilles tendon rupture was treated conservatively and the tendonitis resolved incrementally with st...

journal_title：Annals of clinical and laboratory science

authors： Bunch TJ,Welsh GA,Miller DV,Santhi VS

更新日期：2003-07-01 00:00:00

abstract：:Serum transient paraproteins are small monoclonal immunoglobulins that are induced by a self-limiting regulatory defect in the control of certain terminally differentiated B-cell clones. Relatively uncommon and ill-defined in the medical literature, such proteins may be regarded as immunologic anomalies. Their clinica...

journal_title：Annals of clinical and laboratory science

authors： Strobel SL

更新日期：2003-07-01 00:00:00

abstract：:We previously reported that proper dilution of sera that contain IgG monoclonal proteins (M-proteins) is necessary for accurate quantitation of serum albumin and M-protein concentrations separated by serum protein electrophoresis (SPE) using the Beckman PARAGON agarose electrophoresis system. We now report the signifi...

journal_title：Annals of clinical and laboratory science

authors： Tseng CH,Chang CY,Liu KS,Liu FJ

更新日期：2003-04-01 00:00:00

abstract：:Apolipoprotein (apo) E, like beta-amyloid (Abeta), is a key component of the senile plaques that characterize Alzheimer's disease (AD). Understanding how apoE participates in the formation of senile plaques is necessary to clarify the pathogenesis of AD; however, the mechanism remains unknown. In this study, we invest...

journal_title：Annals of clinical and laboratory science

authors： Yamauchi K,Tozuka M,Hidaka E,Ueno I,Matsuda K,Katsuyama T

更新日期：2003-01-01 00:00:00

abstract：:Syringocystadenoma papilliferum (SP) commonly arises in conjunction with nevus sebaceous. Other less common lesions reported with SP include apocrine adenoma, condyloma acuminatum, hidradenoma papilliferum associated with hidrocystoma, poroma folliculare, and a single case ofverrucous carcinoma. We report the second c...

journal_title：Annals of clinical and laboratory science

authors： Monticciolo NL,Schmidt JD,Morgan MB

更新日期：2002-10-01 00:00:00

abstract：:Point-of-care testing (POCT) has been used for illicit substance screening in several settings, primarily in law enforcement and drug treatment centers. In this study, we evaluate the use of this screening approach in the emergency department (ED) of a tertiary-care, urban medical center. Aliquots of urine specimens w...

journal_title：Annals of clinical and laboratory science

authors： Mastrovitch TA,Bithoney WG,DeBari VA,Nina AG

更新日期：2002-10-01 00:00:00

abstract：:To investigate the relationships between obesity and serum lipid concentrations, we measured eight anthropometric parameters, body mass index (BMI), total body fat (TBF), and serum lipid profiles in 790 apparently healthy adolescents. TBF was assessed using a body fat analyzer. Serum concentrations of triglyceride, to...

journal_title：Annals of clinical and laboratory science

authors： Choi JW,Pai SH,Kim SK

更新日期：2002-07-01 00:00:00

abstract：:While pathogenic T cells have been identified for several diseases with epithelial cell damage, an autoimmune T cell-mediated response targeted against a known keratinocyte antigen has not been reported. Previously we described an autoimmune response directed to the mouse epidermal cell antigens, Skn. For our murine m...

journal_title：Annals of clinical and laboratory science

authors： Jackman SH,Keerthy S,Perry G

更新日期：2002-04-01 00:00:00

abstract：:In a prospective study, M4RT medium was compared to the traditional M4 medium to transport cervical swab specimens for Neisseria gonorrhoeae/Chlamydia trachomatis (NG/CT) PCR testing using the Roche COBAS Amplicor. Two cervical swab samples were collected from 270 consecutive patients screened for NG/CT in a satellite...

journal_title：Annals of clinical and laboratory science

authors： Aslanzadeh J,Jones M

更新日期：2002-01-01 00:00:00

abstract：:Excessive production of hydroxyl radicals in blood and liver has previously been demonstrated by us in rats with obstructive jaundice induced by common bile duct ligation (CBDL). In this study, we demonstrate overproduction of superoxide radicals in circulating blood of CBDL rats by the lucigenin-amplified chemilumine...

journal_title：Annals of clinical and laboratory science

authors： Liu TZ,Lee KT,Chern CL,Cheng JT,Stern A,Tsai LY

更新日期：2001-10-01 00:00:00

abstract：:Determination of creatinine clearance (Ccr) is not a reliable indicator of glomerular filtration rate (GFR), owing to tubular secretion of creatinine. It has been reported that Ccr measurements can approximate true GFR after cimetidine (Ci) administration. In this study, GFR was estimated by Cockcroft and Gault's equa...

journal_title：Annals of clinical and laboratory science

authors： Serdar MA,Kurt I,Ozcelik F,Urhan M,Ilgan S,Yenicesu M,Kenar L,Kutluay T

更新日期：2001-07-01 00:00:00

abstract：:Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to measure 6 metabolic compounds of the adrenocorticosteroid pathway simultaneously on residual specimens from patients who had previously been previously diagnosed, on the basis of immunoassays, as having congenital adrenal hyperplasia (CAH), 11 beta-...

journal_title：Annals of clinical and laboratory science

authors： Kao PC,Machacek DA,Magera MJ,Lacey JM,Rinaldo P

更新日期：2001-04-01 00:00:00

abstract：:The utilization of fibrin sealants to augment hemostasis, seal tissues, and facilitate targeted delivery of drugs is increasing. In 1985, a hospital-based program was established to provide autologous and allogeneic cryoprecipitate that serves as a fibrin sealant when combined with bovine thrombin. To date, more than ...

journal_title：Annals of clinical and laboratory science

authors： Mintz PD,Mayers L,Avery N,Flanagan HL,Burks SG,Spotnitz WD

更新日期：2001-01-01 00:00:00

abstract：:Various fungal products, such as gliotoxin (GT), have immunomodulating activity, a fact exploited previously by our group for prevention of autoimmune diabetes mellitus in BB/Wor rats. To understand better the immunologic effects in GT-treated rats, splenocytes from 65-day-old prediabetic diabetes-prone rats were phen...

journal_title：Annals of clinical and laboratory science

authors： Liu H,Jackman S,Driscoll H,Larsen B

更新日期：2000-10-01 00:00:00

abstract：:Pseudoparaproteins were observed in 129 (10.5%) of 1,229 high resolution protein electrophoretic fractionations of serum (N = 847), urine (N = 368), or cerebrospinal fluid (N = 14) performed in this laboratory during a 12-month period. The pseudoparaproteins identified in serum electrophoretic patterns included fibrin...

journal_title：Annals of clinical and laboratory science

authors： Strobel SL

更新日期：2000-07-01 00:00:00

abstract：:In the course of a clinical comparison involving 204 parallel total creatine kinase (CK), creatine kinase-MB isoenzyme (CK-MB), and cardiac troponin I (cTnI) measurements, 12 patients were identified in whom cTnI was elevated while total CK was normal, as well as 2 patients in whom CK-MB was elevated while cTnI was no...

journal_title：Annals of clinical and laboratory science

authors： Bennett AE,Bertholf RL

更新日期：2000-04-01 00:00:00

abstract：:Pretreatment with heat decreases mortality and acute lung injury in the rat septic shock model, presumably by the production of heat shock proteins (HSP). However, endotoxin, a severe cell stresser, has not been shown to induce HSP 70. We investigated the effects of severe endotoxemia on the expression of specific pro...

journal_title：Annals of clinical and laboratory science

authors： Ofenstein JP,Heidemann S,Juett-Wilstermann A,Sarnaik A

更新日期：2000-01-01 00:00:00

abstract：:Within the next 20-25 years, 20% of the U.S. population is expected to be 65 years old or older. Unless significant changes are made (ie, increased research, improved treatment, and promotion of health and disease prevention), medical costs will continue to rise but with fewer citizens to finance them. However, this n...

journal_title：Annals of clinical and laboratory science

authors： Knight JA

更新日期：2000-01-01 00:00:00

abstract：:An unusual case is reported of pleomorphic large cell sarcoma of the spleen with rhabdomyosarcomatous differentiation in a 34-year old male. According to our knowledge, such a neoplasm has never been reported in the literature. ...

journal_title：Annals of clinical and laboratory science

authors： Gong JZ,Sullivan JD,Teichberg S,Hajdu SI

更新日期：1999-10-01 00:00:00

abstract：:More than 300 million routine clinical analyses are performed annually in the United States. Methods for routine clinical urine examination, including detection of bacteriuria, are briefly reviewed. Prospects of some newer, better techniques to carry out such analyses are introduced. A preliminary report is presented ...

journal_title：Annals of clinical and laboratory science

authors： Lorincz AE,Kelly DR,Dobbins GC,Cardone VS,Fuchs SA,Schilleci JL

更新日期：1999-07-01 00:00:00

abstract：:Traditional risk factors for coronary heart disease (CHD) include only the patient's age and family history and whether there is evidence of hypertension, elevated LDL, low HDL, diabetes or history of smoking. In recent years, considerable progress has been made in identifying a new generation of risk factors, includi...

journal_title：Annals of clinical and laboratory science

authors： Wu LL

更新日期：1999-04-01 00:00:00

abstract：:Desmoplastic small round cell tumors (DSRCT) are highly aggressive tumors typically involving the serosal surfaces of the peritoneum. Patients often present with abdominal pain, an abdominal mass, ascites or signs of intestinal obstruction. Cytogenetic and molecular studies have identified a characteristic t(11;22)(p1...

journal_title：Annals of clinical and laboratory science

authors： Froberg K,Brown RE,Gaylord H,Manivel C

更新日期：1999-01-01 00:00:00

abstract：:Oxygen toxicity was first described in laboratory animals in 1878 and was further established in 1899. The first experiment regarding a free radical reaction was reported in 1894. However, it was not until the late 1940s to early 1950s that retrolental fibroplasia in premature newborns was recognized as being due to o...

journal_title：Annals of clinical and laboratory science

authors： Knight JA

更新日期：1998-11-01 00:00:00

abstract：:Lidocaine, quinidine, and theophylline binding to normal pooled mature human milk was determined using equilibrium dialysis at 4 degrees C. Binding to milk was compared with binding to pooled human serum. The observed binding was related to the relative lipid solubility of each drug in milk. The potential for the excr...

journal_title：Annals of clinical and laboratory science

authors： Bailey DN

更新日期：1998-09-01 00:00:00

abstract：:Spermatogenesis is severely altered in the nonobese diabetic (NOD) mouse in the presence of diabetes. When insulin is administered early in the development of diabetic changes, blunting of the testicular damage results, suggesting a direct causal effect of hyperglycemia on the testicular alterations. In view of the ke...

journal_title：Annals of clinical and laboratory science

authors： Gondos B,Rivkind Y,Jovanovic L

更新日期：1998-07-01 00:00:00

abstract：:The literature was reviewed to investigate the existence of unique gastrointestinal (GI) pathological lesions in sickle-cell disease (SCD). Chole- and choledocholithiasis have long been recognized, but bilirubin gallstones can occur in any chronic hemolytic anemia. Acute pancreatitis has been reported as a possible is...

journal_title：Annals of clinical and laboratory science

authors： Krauss JS,Freant LJ,Lee JR

更新日期：1998-01-01 00:00:00

abstract：:Experimental evidence documenting the formation of a relatively stable V(IV) species appears to be important with regard to the biochemical mechanism of reduction of vanadate by enzymatic systems. The present study demonstrates that a mixture of vanadate and glutathione reductase/nicotinamide-adenine-dinucleotide phos...

journal_title：Annals of clinical and laboratory science

authors： Shi X,Flynn DC,Liu K,Dalal N

更新日期：1997-11-01 00:00:00

abstract：:Aeromonas hydrophila has emerged as a potential pathogen in the immunocompromised host. Various aeromonal infections, including septicemia, have also been reported in apparently healthy individuals. For years, researchers have disagreed over the epidemiologic roles of aeromonads in gastroenteritis. Isolation rates of ...

journal_title：Annals of clinical and laboratory science

authors： Chang CY,Thompson H,Rodman N,Bylander J,Thomas J

更新日期：1997-07-01 00:00:00

abstract：:Lipoprotein lipids and apo B from 254 male patients were compared with bilirubin as a risk factor for coronary artery disease (CAD). Patients were classified as: 1, Normal, all vessels < 20% stenosis, n = 83; or 2, CAD, at least one vessel > 70%, n = 171. Diagnostic accuracy was assessed by receiver operator character...

journal_title：Annals of clinical and laboratory science

authors： Levinson SS

更新日期：1997-05-01 00:00:00

abstract：:The aging process in man leads to some loss of kidney mass and function. The kidney produces epidermal growth factor (EGF), a polypeptide involved in the repairing process of epithelial cells. Human urine contains high concentrations of EGF, derived from its production in the kidney. It is not known if aging alters ur...

journal_title：Annals of clinical and laboratory science

authors： Chou JS,Reiser IW,Porush JG

更新日期：1997-03-01 00:00:00

abstract：:Nitric oxide is generated from L-arginine by the action of nitric oxide synthase, an enzyme encoded by three different genes. Nitric oxide is involved in an expanding number of phenomena. This involvement may be documented by direct detection using spectrophotometric or electrochemical methods or more often by indirec...

journal_title：Annals of clinical and laboratory science

authors： Kiechle FL,Malinski T

更新日期：1996-11-01 00:00:00